|
KMID : 1039920130200040428
|
|
Neonatal Medicine
2013 Volume.20 No. 4 p.428 ~ p.437
|
|
|
Seizure Scoring System and Neurodevelopmental Outcomes in Very Low Birth Weight Infants with Neonatal Seizures
|
|
Kim Hyun-Jin
Lee Byong-Sop
Yum Mi-Sun
Jang Hee-jin
Oh Seong-Hee
Do Hyun-Jeong
Chung Sung-Hoon
Ko Tae-Sung
Kim Ai-Rhan
Kim Ki-Soo
|
|
|
Abstract
|
|
|
Purpose: To evaluate the utility of seizure scoring system in the prediction of neurodevelopmental outcomes in very low birth weight (VLBW) infants who presented with neonatal seizures.
Methods: A retrospective review was performed in VLBW infants who were treated with antiepileptic drugs (AED) for the control of neonatal seizures. A total of 25 infants who survived and were followed-up for at least 2 years of age were included. A new seizure scoring system (the composite score 0-8) was constructed by choosing the following variables: onset, response to the AED, presence of status epilepticus, seizure types and EEG findings including background activity and epileptiform discharges. Neurodevelopmental outcomes were graded from 1 to 5 based on the developmental status and the neurologic abnormalities assessed at 18 to 24 months of postconceptional age. Risk factor analyses for predicting unfavorable outcomes (grade 3-5) versus favorable outcomes (grade 1-2) were performed.
Results: Compared to favorable outcome group (n=11), unfavorable outcome group (n=14) had higher incidence of subtle or generalized tonic-type seizures, the abnormal EEG background activity and poor response to AED. The composite seizure score was significantly higher in the unfavorable outcome group (3.2±0.7) than in the favorable outcome group (1.2±1.2) and it significantly correlated with the neurodevelopmental grading (P<0.001). In multivariate analysis, abnormal MRI findings at term and the composite seizure score were significant risk factors for unfavorable outcomes.
Conclusion: In VLBW infants with neonatal seizure, the proposed seizure scoring system was a simple and useful predictor of long-term neurologic outcomes.
|
|
|
KEYWORD
|
|
|
Neonatal seizure, Seizure scoring system, Very low birth weight infant, Neurodevelopmental outcome
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|